Modern perspectives of societal transformation and economic growth and prosperity require rudimentary elements of sustainable development goals that need rethinking, partnership and participation of people, professionals, organizations and communities. Sustainable development goals and targets offer new opportunities to address societal issues because many poor people need economic prosperity and social inclusion. African countries have been affected by underdevelopment and interdependence of growth practices characterized by extreme poverty, ignorance and health problems due to social inequalities, poor economic policies and solutions as well as endless political wars and conflicts. Despite the adoption of the initial millennium development goals (MDGs), poverty levels, inadequate food, lack of access to clean drinking water and sanitation, and inequalities have continued to dominate and affect human life. The sustainable development goals deal with information, knowledge, technology and people that have neither local limitations nor geopolitics, although research on this novel strategy in the information discipline and profession is new and emerging. Leveraging the rethinking of information science in sustaining societal transformation in rural communities that normally form the largest segment of the population affected by underdevelopment, poverty and diseases is fundamental in the modern digital economy and knowledge society.