Among the sectors that seem indifferent towards considering sustainability as a strategy or intent, healthcare was one of the most emblematic cases, even though it is facing great challenges in its structure, organization, service delivery and operations. Within this context, the development of new paradigms of healthcare delivery that may be sustainable over time is becoming an imperative. With this regard, technology has drawn increasing attention as one of the “emerging service delivery vehicles running on the information highway” and its application to healthcare has been denominated e-health. Despite the enthusiasm, not much is understood about how to make these changes factual and, above all, in line with the challenge of sustainable development. Specialized research provides little insight into why there is so little routine use of technologies in clinical practice: this is the reason why, in recent years, studies on the organizational sustainability have emerged.