Reselling expired pharmaceuticals in Egypt is an increasing problem with severe consequences (Ramadan, 2014; RASSD, 2015). Recent studies by Kabir (2013); Kwateng, Debrah, Parker, Owusu, and Prempeh (2014) suggest extended focus on reverse logistics to potentially reduce this problem. There are however several barriers which hinder or prevent the application of reverse logistics in pharmaceutical industry. Accordingly, this research attempt to explore these barriers that hinder or prevent the application of reverse logistics practices at a leading pharmaceutical manufacturer in Egypt.