Comparative Study of 4-Compartmental PK-PD Model with Effective Site Compartment for Different Parameter Set

Comparative Study of 4-Compartmental PK-PD Model with Effective Site Compartment for Different Parameter Set

UshaRani Shola, V Neelanarayanan
Copyright: © 2019 |Pages: 14
DOI: 10.4018/IJRQEH.2019010105
OnDemand:
(Individual Articles)
Available
$37.50
Current Special Offers
No Current Special Offers
TOTAL SAVINGS: $37.50

Abstract

Target-controlled infusion pumps are for patients to control pain or to infuse sedations and anesthesia, typically those who underwent surgery. The pump has a programmable syringe device used to control the injection level of drugs. These pumps are even used in the ICU or operating theaters to manage patient's pain after surgery or sedation. PK-PD Models are used to obtain the drug concentrations levels of the patient. The model depends on the drug flow rates in different parts of the body. There are many parameter sets available to measure the amount of drugs in the patients. This article presents a three compartmental patient model through Simulink to obtain concentrations levels from different parts of the body. The model is checked for a seven parameter set and suggests the set with the best results.
Article Preview
Top

Background

The patient model for drug infusion is the process of administrating drug into the patient body through mathematical model. There are basically two patient models involved for knowing the drug interaction with human body.

Complete Article List

Search this Journal:
Reset
Volume 13: 1 Issue (2024): Forthcoming, Available for Pre-Order
Volume 12: 2 Issues (2023)
Volume 11: 4 Issues (2022)
Volume 10: 4 Issues (2021)
Volume 9: 4 Issues (2020)
Volume 8: 4 Issues (2019)
Volume 7: 4 Issues (2018)
Volume 6: 4 Issues (2017)
Volume 5: 4 Issues (2016)
Volume 4: 4 Issues (2015)
Volume 3: 4 Issues (2014)
Volume 2: 4 Issues (2013)
Volume 1: 4 Issues (2012)
View Complete Journal Contents Listing